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Patients addressed with flumazenil need to be monitored for re-sedation, respiratory depression, and various residual benzodiazepine consequences for an appropriate time period immediately after remedy. The prescriber should concentrate on a hazard of seizure in Affiliation with flumazenil therapy, notably in very long-expression benzodiazepine users and in cyclic antidepressant overdose. The whole flumazenil offer insert need to be consulted ahead of use.
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Use with digoxin: enhance the chance of digoxin toxicity. Use with CYP3A inhibitors (apart from ritonavir): increase the threat of adverse reactions of alprazolam. Use with CYP3A inducers: enhance the threat of reduced efficacy of Xanax.
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